The 2007 Stanford vs. USC football game was an NCAA college football game held on October 6, 2007, at the Los Angeles Memorial Coliseum in Los Angeles, California. In a remarkable upset, the visiting Stanford Cardinal won 24–23 despite USC having been favored by 41 points entering the game. This result was the biggest point spread upset of all time in college football (since surpassed by the Howard University Bison in 2017, who were 45-point underdogs heading into a road game against the UNLV Rebels). USC entered the game with a 35-game home game winning streak (its previous home game loss also happened to be to Stanford, in 2001) which included a 24-game home game winning streak in Pac-10 play. By contrast, Stanford had compiled a Pac-10 worst 1–11 season in 2006, which included a 42–0 loss to USC. To compound the situation, Stanford's starting quarterback T. C. Ostrander had suffered a seizure the week before and his replacement, backup quarterback Tavita Pritchard, had never started a game and had thrown just three passes in official play.

The weather was sunny and 74 °F (23 °C) with a slight west wind. The game began at 4:09pm Pacific Daylight Time and ended at 7:36pm.

The final score was announced at the Rose Bowl, where USC's two arch-rivals, UCLA and Notre Dame, were playing each other. Irish and Bruins fans cheered in unison and celebrated together briefly. At the same time, at Tiger Stadium, the #1 LSU Tigers were playing the #9 Florida Gators and the fans in the stadium celebrated when the USC score was announced there, too. The Tigers would later come from behind to beat the Gators 28–24, making them #1 in both polls with USC dropping from #1 in the coaches poll due to the loss.

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