The 2007 American League Championship Series (ALCS), the second round of the 2007 American League playoffs, began on October 12 and ended on October 21. It was a best-of-seven series, with the East Division champion Boston Red Sox facing the Central Division champion Cleveland Indians. The Red Sox came back from a 3–1 deficit to defeat the Indians 4–3, outscoring them 30–5 over the final three games of the Series.

The Red Sox had swept the Los Angeles Angels of Anaheim in three games in the AL Division Series, while the Indians had defeated the New York Yankees three games to one. The series marks the fourth postseason meeting of the two teams, following the 1995 and 1998 AL Division Series, both of which were won by the Indians, and the 1999 ALDS, won by the Red Sox (in a similar fashion to this series). It was the eighth ALCS appearance for Boston, and the fourth for Cleveland.

The series was broadcast on Fox television.

Boston won the series, 4–3.

Friday, October 12, 2007 at Fenway Park in Boston

In Game 1, the Cleveland Indians took the lead when Travis Hafner hit a home run to deep right field in the first inning against Josh Beckett, who retired the next ten batters in a row, finishing by striking out seven while allowing only two runs in six innings pitched. The Red Sox tied the game in the bottom of the inning off of CC Sabathia on three straight one-out singles by Kevin Youkilis, David Ortiz, and Manny Ramirez. In the third, the Red Sox loaded the bases with one out on a double, walk, and hit by pitch before Ramirez walked to force in a run, then Mike Lowell's ground-rule double scored two more. After Bobby Kielty was intentionally walked, Jason Varitek's groundout put Boston up 5-1. In the fifth, the Red Sox again loaded the bases on a single and two walks when Kielty's single scored two with Lowell being tagged out at third. Jensen Lewis relieved Sabathia and allowed an RBI double to Varitek. Sabathia was charged with eight runs on seven hits in 4 1/3 innings. Casey Blake doubled to lead off the top of the sixth and scored on Asdrúbal Cabrera's single one out later. Dustin Pedroia and Youkilis hit back-to-back singles to lead off the bottom of the sixth. Aaron Fultz relieved Lewis and walked two to load the bases and force in a run. Tom Mastny relieved Fultz and allowed a sacrifice fly to Lowell to put the Red Sox up 10-2. The Indians scored their last run in the top of the eighth off of Javier López when Blake hit a leadoff double, moved to third on a fly out, and scored on Cabrera's sacrifice fly. They load the bases with two outs off of Eric Gange in the ninth, but Grady Sizemore struck out on a full count to end the game as the Red Sox went up 1-0 in the series.

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