The 2007–08 Major Indoor Soccer League season is the seventh season for the league. The MISL had three new expansion teams to start the season: the Monterrey La Raza, Orlando Sharks, and New Jersey Ironmen. Each team played 15 home and 15 away games.
The season started with the Baltimore Blast taking on the Philadelphia KiXX at the 1st Mariner Arena on October 19, 2007 at 8:35pm. The season ended April 26, 2008 with the Baltimore Blast defeating the Monterrey La Raza for the MISL Championship at the U.S. Cellular Arena in Milwaukee, Wisconsin.
The league ceased operations after the season.
Blue indicates first round bye clinched
Green indicates playoff berth clinched