Though it did not produce silverware, Futbol Club Barcelona's 2007–08 season would mark a period of change within the club, having many firsts and lasts. Most importantly, this would be Ronaldinho's last season with the club, being displaced by the coming of Arsenal legend Thierry Henry. This season also marked the breakthrough of young talent Bojan into the first team, as well as the emergence of Lionel Messi as one of the team's key players. On the other hand, this would be Lilian Thuram's last season as a professional footballer, as well as Gianluca Zambrotta's last with the club.

The squad has reasonably changed in the summer transfer window. The biggest addition was Thierry Henry, with a transfer fee of €24 millions. That equals the transfer fee paid for Samuel Eto'o in 2004, but just below the €30 million paid for Ronaldinho in 2003. Other additions were Éric Abidal, Yaya Touré, and Gabriel Milito that are part of the current start team. On the other end, some important players that were often used last season have left the club, such as, Giovanni van Bronckhorst and Ludovic Giuly. Barcelona still used a great number of players developed in its youth system, 9 of 23, and have two new additions this season: Giovani dos Santos and Bojan (17 years old, the youngest player on the squad).

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