The 2006 NCAA Division I Men's Basketball Championship Game was the finals of the 2006 NCAA Division I Men's Basketball Tournament and it determined the national champion for the 2005-06 NCAA Division I men's basketball season. The 2006 National Title Game was played at the RCA Dome in Indianapolis, Indiana. The 2006 National Title Game was played between the 2006 Oakland Regional Champions, No.2-seeded UCLA and the 2006 Minneapolis Regional Champions, No.3-seeded Florida.

Florida entered the 2006 NCAA Tournament as the No.3 seed in the Minneapolis Regional. In the 1st round of the 2006 NCAA Tournament, Lee Humphrey scored 20 points, Joakim Noah scored 16 points, and Al Horford scored 14 points to lead Florida past South Alabama with a 76-50 victory. In the 2nd round of the 2006 NCAA Tournament, Corey Brewer scored 23 points and Joakim Noah scored 17 points to rout Milwaukee with a 82-60 victory. In the Sweet 16 of the 2006 NCAA Tournament, Corey Brewer made a twisting falling down shot which became a three-point play with 27.5 seconds remaining to defeat Georgetown 57-53 and advance to the Elite Eight. In the Elite Eight of the 2006 NCAA Tournament, Joakim Noah had a monster night by scoring 21 points which led to Florida beating Villanova 75-62 and advancing to the 2006 Final Four. In the 2006 Final Four, Florida had a successful night from outside the arch to beat George Mason 73-58 for a trip to the 2006 National Title Game.

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