The 2006 Gaylord Hotels Music City Bowl (presented by Bridgestone) featured a contest between the Clemson Tigers and the Kentucky Wildcats. Clemson entered the game with a record of 8-4 after having been ranked in the AP poll for most weeks of the season, as high as #10; Kentucky was 7-5 and unranked. Clemson was favored by 10 points.

Micah Johnson scored on a 1-yard touchdown run to give Kentucky a 7–0 lead over Clemson. Clemson quarterback Will Proctor then fired a 32-yard touchdown pass to wide receiver Durrell Barry, but the extra point missed, and Kentucky still led 7–6. Kentucky quarterback André Woodson found wide receiver DeMoreo Ford for a 70-yard touchdown pass with 2:14 left in the half to take a 14–6 lead.

In the third quarter, Woodson found Dicky Lyons, Jr. for a 24-yard touchdown pass and a 21–6 lead. In the fourth quarter, Woodson threw a 13-yard touchdown pass to Jacob Tamme for a 28–6 lead. Will Proctor threw a 17-yard touchdown pass with 7:25 left, to get within 28–12. The 2-point conversion attempt failed. With 44 seconds left, Will Proctor threw a 17-yard touchdown pass to wide receiver Aaron Kelly. The 2-point conversion attempt to Michael Palmer was good, and Clemson trailed 28–20. The onside kick was recovered by Kentucky, who ran out the clock.

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