The 2006 McDonald's All-American Boys Game was an All-star basketball game played on Wednesday, March 29, 2006 at Cox Arena in San Diego, California, home of the San Diego State University. The game's rosters featured the best and most highly recruited high school boys graduating in 2007. The game was the 29th annual version of the McDonald's All-American Game first played in 1978.

The 48 players were selected from 2,500 nominees by a committee of basketball experts. They were chosen not only for their on-court skills, but for their performances off the court as well. Coach Morgan Wootten, who had more than 1,200 wins as head basketball coach at DeMatha High School, was chairman of the selection committee. Legendary UCLA coach John Wooden, who has been involved in the McDonald's All American Games since its inception, served as chairman of the Games and as an advisor to the selection committee.

Proceeds from the 2006 McDonald's All American High School Basketball Games went to Ronald McDonald House Charities (RMHC) of San Diego and its Ronald McDonald House program.

The game was telecast live by ESPN. The halftime performance by hip hop artist Nick Cannon took second stage to the showcase of basketball talent at the 2006 McDonald’s All American Games.

A sold-out boys' game was headlined by hometown favorite and co-Most Valuable Player of the Game, Chase Budinger (Houston Rockets), who had 11 points, four assists, three steals and three rebounds. He shared the John R. Wooden Most Valuable Player Award with West-squad teammate Kevin Durant (Oklahoma City Thunder), who racked-up 25 points, five rebounds, four assists and two steals. The East Team was led by Gerald Henderson (Charlotte Bobcats) with 16 points and Thaddeus Young (Philadelphia Sixers) with 14 points. Morgan Wootten Player of the Year award winner and boys' East Team player Greg Oden (Portland Trail Blazers) also had a stellar game with 10 points, five rebounds and four blocks despite an injured right wrist.

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