During the 2006–07 English football season, Brentford competed in Football League One. The club finished bottom of the league and was relegated to Football League Two.

After defeat in the 2006 League One play-off semi-finals, Brentford were rocked by the resignation of popular manager Martin Allen on 30 May 2006. Chairman Greg Dyke revealed that Allen's departure was due to the cash-strapped club's wage budget being reduced for the 2006–07 season, despite an FA Cup run and the £500,000 sale of DJ Campbell during 2005–06. Chief scout John Griffin handled first team affairs until the appointment of Leroy Rosenior as manager on 14 June. Despite the summer sales of star players Jay Tabb, Michael Turner and Sam Sodje generating upwards of £1,000,000, Rosenior was forced to bring in players on free transfers, building a new spine for the team with centre backs Adam Griffiths and Matthew Heywood, midfielder Thomas Pinault and forwards Jo Kuffour and Chris Moore.Goalkeeper Stuart Nelson, full backs Andy Frampton and Kevin O'Connor, midfielders Ólafur Ingi Skúlason, Paul Brooker, Alex Rhodes and strikers Lloyd Owusu and Calum Willock remained from Martin Allen's first-choice squad from the previous season, though Owusu would miss much of the campaign with a groin injury.