The 2006-07 season of the Belgian First Division began on July 28, 2006 and concluded on May 19, 2007. The championship was decided in the penultimate round on May 12, 2007, when Anderlecht moved five points clear of runners-up Genk to retain the title and win their 29th League Championship. At the other end of the table, the struggle to avoid automatic relegation went on until the final round, and it was Lierse who eventually prevailed. Having spent the entire season at the bottom of the standings and only just managed to close an eleven-point gap up to 17th, the Lier side won their last game to climb past Beveren and send the latter down to the Second Division. However, Lierse went on to lose the playoffs and was relegated anyway.
Eighteen teams played in the 2006-07 first division. Twelve teams were from Flanders, four clubs from Wallonia and just two clubs from the Brussels-Capital Region.
La Louvière had been relegated at the end of the previous season with Mons replacing them as they won the Belgian Second Division. Lierse had managed to win the promotion playoff and thus they remained in the first division.
[1]R.S.C. Anderlecht competed in the UEFA Cup First Round after losing in the Champions League Third Qualifying Round.