The 2005 National League Division Series (NLDS), the opening round of the 2005 National League playoffs, began on Tuesday, October 4, and ended on Sunday, October 9, with the champions of the three NL divisions—along with a "wild card" team—participating in two best-of-five series. They were:

The higher seed (in parentheses) had the home field advantage, which was determined by playing record. Although the team with the best record was normally intended to play the wild card team, the Cardinals played the Padres, rather than the wild card Astros, because the Cardinals and Astros are in the same division.

The Cardinals and Astros went on to meet in the NL Championship Series (NLCS). The Astros became the National League champion, and lost to the American League champion Chicago White Sox in the 2005 World Series.

St. Louis won the series, 3–0.

Houston won the series, 3–1.

Busch Stadium (II) in St. Louis, Missouri

It was a matchup between Jake Peavy and eventual 2005 Cy Young Award winner Chris Carpenter. In the bottom of the first, Jim Edmonds's one-out solo homer put the Cardinals up 1–0. Then in the bottom of the third, Peavy's control slipped away as a wild pitch and a two-run single by Reggie Sanders gave the Cards a 4–0 lead. But Sanders would provide more offense with a grand slam in the fifth. That would make the score 8–0 and give Sanders six RBIs in the game. The Padres would not go quietly though. They would scratch out a run in the seventh on a sac fly, then one more on a solo homer by Eric Young in the eighth. After the Padres put runners on the corners in the ninth, Jason Isringhausen came on to close the deal. But four consecutive hits with two outs would make the score 8–5 and would load the bases with the go-ahead run at the plate. Ramón Hernández would not deliver as he would strike out to end the game.

...
Wikipedia