The 2005-06 season in the Primera División Uruguaya saw Nacional defend and win a back-to-back-title by defeating the surprise of the championship, Rocha F.C., on two consecutive finals, thus winning their 41st title in Uruguayan football. Two teams were relegated, Deportivo Colonia and Cerro, but this time only one team, Progreso, was promoted.
Statistics of Primera División Uruguaya in season 2005/2006.
It was contested by 20 teams, and Nacional won the championship.