Despite the loss of several key players following their unexpected run to the UEFA Champions League semi-final, PSV secured a second successive Eredivise title. However, they were unable to defend the KNVB Cup, losing to Ajax in the final, and were knocked out in the Champions League first knockout round by Lyon.

At the end of the season, manager Guus Hiddink, who had concurrently managed the Australia national team, left to manage the Russia national team. He was succeeded as PSV manager by Ronald Koeman

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

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