The Greek Cup 2005–06 was the 64th staging of The Greek Football Cup, or Greek Cup, competition. This season's edition was the first to be entitled "SINCO Greek Cup" after SINCO Insurance Brokers.
The competition started on 20 August 2005 and concluded on 10 May 2006 with the Final, held at the Pankritio.
Olympiacos claimed this season's Greek Cup with a 3-0 victory over AEK Athens.