The 2004 American League Championship Series was the Major League Baseball playoff series to decide the American League champion for the 2004 season. It was played between the Boston Red Sox and New York Yankees, at Fenway Park and the original Yankee Stadium, from October 12 to 20, 2004. The Red Sox became the first (and so far only) team in MLB history to come back from a 0–3 deficit to win a seven-game series. The Red Sox, who had won the AL wild card, defeated the Anaheim Angels in the American League Division Series to reach the ALCS, while the Yankees, who had won the AL East with the best record in the AL, defeated the Minnesota Twins.

In Game 1, Yankees pitcher Mike Mussina pitched a perfect game through six innings, while the Red Sox recovered from an eight-run deficit to close within one run before the Yankees eventually won. A home run by John Olerud helped the Yankees win Game 2. The Yankees gathered 22 hits in Game 3 on their way to an easy win. The Yankees led Game 4 by one run in the ninth inning, but a steal of second base by Red Sox base runner Dave Roberts and a single by Bill Mueller off Yankees closer Mariano Rivera tied the game. A home run by David Ortiz then won it for the Red Sox in extra innings. Ortiz also won Game 5 with a single in the fourteenth inning. Curt Schilling pitched seven innings in Game 6 for the Red Sox, during which time his sock became soaked in blood. Game 7 featured the Red Sox paying back New York for their Game 3 blowout with a dominating performance on the road, anchored by Derek Lowe and bolstered by two Johnny Damon home runs, one a grand slam. David Ortiz was named the Most Valuable Player of the series.

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