During the 2004–05 English football season, Portsmouth competed in the FA Premier League. It was Portsmouth's second consecutive season in English football's top-flight.

Portsmouth's campaign got off to a good start, winning four of their first ten games including the famous, brilliant 2-0 win over Manchester United as they maintained a strong mid-table position in late October. However, manager Harry Redknapp walked out on Portsmouth in November after a row with chairman Milan Mandaric over the appointment of new Director of Football Velimir Zajec at the club. Zajec replaced Redknapp as manager with immediate effect, but under his management the club's form dipped, bringing the club from the top ten to a few points above the relegation zone. In April, Zajec was replaced by Frenchman Alain Perrin; Perrin managed to secure Portsmouth's Premiership status with a few games of the season left. Despite this, Portsmouth still played a pivotal role in the "Survival Sunday" relegation drama - by losing 2–0 at West Bromwich Albion they both secured Albion's Premiership status and helped relegate arch-rivals Southampton (although Southampton were beaten 2–1 at home by Manchester United and would have been relegated even if Albion had lost).

Portsmouth retained the previous season's kit, manufactured under the club's own brand, Pompey Sport.

Note: Flags indicate national team as defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.

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