The 2000 American League Championship Series (ALCS) was a matchup between the East Division champion New York Yankees and the Wild Card Seattle Mariners. The Yankees had advanced to the Series after beating the West Division champion Oakland Athletics in the ALDS three games to two and the Mariners advanced by beating the Central Division champion Chicago White Sox three games to none. The Yankees won the Series four games to two and went on to defeat the New York Mets in the World Series.

New York won the series, 4–2.

Tuesday, October 10, 2000 at Yankee Stadium (I) in Bronx, New York

Game 1 at Yankee Stadium started as a pitchers' duel between Mariners' Freddy García and Yankees' Denny Neagle. Neither team would score until the top of the fifth when Mark McLemore hit a two-out ground rule double off Neagle before scoring on a Rickey Henderson single. Alex Rodriguez homered in the sixth to make it 2–0 Mariners. The Yankees could not score any runs off García or three Mariner relievers and Seattle took a 1–0 series lead.

Wednesday, October 11, 2000 at Yankee Stadium (I) in Bronx, New York

In Game 2, the Yankees' offense was again dead silent, this time against Mariner starter John Halama and reliever José Paniagua. Yankees starter Orlando Hernández pitched eight innings giving up just one run, a John Olerud single in the third that scored Mike Cameron, who walked and stole second, on six hits, but was set to get the loss until the Yankees' offense exploded in the eighth against Arthur Rhodes and José Mesa. David Justice led off with a double before scoring on a Bernie Williams single to tie the game. Back-to-back singles by Tino Martinez and Jorge Posada then gave the Yankees 2–1 lead. Paul O'Neil then hit a sacrifice fly to make a 3–1 game. Mesa replaced Rhodes pitching and gave up a single to Luis Sojo. After Posada was caught stealing for the second out, José Vizcaíno doubled to score Sojo and make it 4–1 Yankees. Vizcaíno would score on a Chuck Knoblauch single before Derek Jeter homered to make it a 7–1 Yankees lead. Mariano Rivera pitched a scoreless ninth and the series was tied 1–1 head to Seattle.

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