The 2000–01 season was the 121st season of competitive football in England.
Manchester United secured their 3rd Premiership title in succession and their 7th title in just nine seasons. Liverpool became only the second English side to win the League Cup and FA Cup in the same season and added the UEFA Cup to make it a unique treble.
Fulham reached the Premiership as Division One champions to secure their five-season rise from Division Three. They also became the first club to have played in all four divisions of the English league since the creation of the Premiership.
Arguably two of the most famous clubs outside the Premiership fell into Division Three. They were Luton Town – who had been League Cup winners 13 years earlier and top division members until 9 years ago – and Oxford United – who had been League Cup winners 15 years earlier and top division members until 13 years ago.
Mid-table Division Two side Wycombe Wanderers beat all odds by reaching the FA Cup Semi-Final versus Liverpool, having beaten Division One sides Millwall, Wolves, Wimbledon and a very strong Premiership Leicester City en route. Wycombe were beaten 2–1 at Villa Park, Keith Ryan scoring the Chairboys' goal.