The 2000–01 season was Manchester United's ninth season in the Premier League, and their 26th consecutive season in the top division of English football. United won the Premier League for the third successive season and the seventh time since its inauguration in 1993. They were less successful in cup competitions, going out in the fourth round of the FA Cup, the fourth round of the League Cup and the quarter-finals of the Champions League.

New goalkeeper Fabien Barthez was an instant success, and previous first choice goalkeeper Mark Bosnich failed to feature in the first team in 2000–01, opting to join Chelsea on a free transfer in January, despite equally limited first team opportunities at Stamford Bridge. Veteran striker Teddy Sheringham had an excellent season, topping the club's goalscoring charts and gaining both the PFA and FWA player of the year awards. However, the arrival of Dutch striker Ruud van Nistelrooy from PSV Eindhoven at the end of the season prompted Sheringham to return to Tottenham on a free transfer. Also on his way out of the Old Trafford exit door was Henning Berg, who was loaned to his old club Blackburn just after the start of the season, and moved on a permanent contract in December, joining former United players John Curtis and Mark Hughes in Blackburn's successful campaign that saw them promoted back to the Premier League after a two-year exile.

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