The 2000–01 NBA season was the thirteenth season for the Charlotte Hornets in the National Basketball Association. During the offseason, the Hornets acquired Jamal Mashburn, P.J. Brown and Otis Thorpe from the Miami Heat, and re-signed free agent Hersey Hawkins. With the acquisitions of Mashburn and Brown along with veterans David Wesley and Elden Campbell, plus an increased role for second-year guard Baron Davis, the Hornets finished the season third in the Central Division with a 46–36 record, and qualified for their sixth Playoff appearance. In the playoffs, the players all wore headbands to show team unity. The Hornets swept the 3rd-seeded Miami Heat in three straight games in the Eastern Conference First Round, but were eliminated by the Milwaukee Bucks three games to four in the Conference Semifinals after taking a 3–2 series lead. Following the season, Derrick Coleman was traded back to the Philadelphia 76ers, and Hawkins and Thorpe both retired.

The Hornets finished twenty-first in the NBA in attendance for the season.

(3) Miami Heat vs. (6) Charlotte Hornets Last Playoff Meeting: This is the first meeting between the Heat and Hornets.

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(2) Milwaukee Bucks vs. (6) Charlotte Hornets Last Playoff Meeting: This is the first meeting between the Bucks and Hornets.

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