The 2000–01 NBA season was the 55th season for the Boston Celtics in the National Basketball Association. During the offseason, the Celtics acquired Bryant Stith from the Denver Nuggets. The Celtics played around .500 in November, but then struggled as Kenny Anderson played just 33 games due to an ankle injury and broken jaw. With a 12–22 start to the season, a frustrated Rick Pitino resigned as head coach after three years with the Celtics. Under replacement Jim O'Brien, they played around .500 for the rest of the season finishing fifth in the Atlantic Division with a 36–46 record, missing the playoffs for the sixth consecutive season. In the 39 years before the current streak, they had missed the playoffs only five times. Paul Pierce led the team in scoring with 25.3 points per game, and Antoine Walker led the league with 221 three-point field goals. Following the season, Stith signed as a free agent with the Cleveland Cavaliers.

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