The 1995 American League Championship Series (ALCS), the second round of the 1995 American League playoffs, matched the Central Division champion Cleveland Indians against the West Division champion Seattle Mariners. The Mariners had the home field advantage, which was predetermined and assigned to either the West Division champion or their opponents in the Division Series.

The two teams were victorious in the AL Division Series (ALDS), with the Indians defeating the East Division champion Boston Red Sox three games to none, and the Mariners defeating the wild card qualifier New York Yankees three games to two. The Indians won the series four games to two to become the American League champions, and lost to the National League champion Atlanta Braves in the 1995 World Series.

Cleveland won the series, 4–2.

Tuesday, October 10, 1995, at Kingdome in Seattle, Washington

The Indians called on the veteran Dennis Martínez for Game 1. The Mariners rode the arm of Bob Wolcott. Wolcott got off to a shaky start by walking three straight hitters to open the game, but he would get out of the bases-loaded, nobody-out situation with ease. In the second, Mike Blowers hit a two-run homer to put the Mariners in front 2–0. However, the Indians would put together a run in the next inning and in the seventh, Albert Belle's solo homer tied the game at two. With Martinez still pitching in a tie game, the Mariners would take the lead thanks to Luis Sojo's go-ahead double in the bottom half of the seventh. Norm Charlton would come on in the eighth for a 1 ¹⁄₃ inning save. He would retire the side 1–2–3 in the ninth.

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