The Second League of Yugoslavia's 1991/1992 season was the last in which teams from Bosnia and Herzegovina and Macedonia participated, as well as the last of the Socialist Federal Republic of Yugoslavia in general as the Second League of FR Yugoslavia was established the following season. In 1992 these republics declared their independence from Yugoslavia. The clubs from Croatia and Slovenia were already playing their first seasons as separate nations.
FK Bečej was the league champion with 49 points, and together with FK Hajduk Kula, FK Radnički Beograd, FK Mogren, OFK Kikinda, FK Priština and FK Napredak Kruševac getting the promotion to the 1992–93 First League of FR Yugoslavia.
FK Sloboda Užice, FK Radnički Kragujevac, FK Mačva Šabac, FK Borac Čačak, FK Vrbas, FK Jedinstvo Bijelo Polje and FK Bor booked their places in next seasons 1992–93 Second League of FR Yugoslavia.