The 1988 Liberty Bowl, part of the 1988 bowl game season, took place on December 28, 1988, at the Liberty Bowl Memorial Stadium in Memphis, Tennessee. The competing teams were the South Carolina Gamecocks, who competed as a I-A independent, and the Indiana Hoosiers of the Big Ten Conference (Big 10). In what was the first ever meeting between the schools, Indiana was victorious in by a final score of 34–10.

The 1988 South Carolina squad finished the regular season with losses at Georgia Tech and Clemson and at home to Florida State en route to an overall record of eight wins and three losses (8–3). After their loss to Clemson in the regular season finale on November 19, the Gamecocks publicly accepted an invitation to play in the Liberty Bowl. The appearance marked the first for South Carolina in the Liberty Bowl, and their eighth overall bowl game.

The 1988 Indiana squad finished the regular season with a tie at Missouri and losses against Michigan, Illinois and Michigan State en route to an overall record of seven wins, three losses and one tie (7–3–1). In mid-November, the Hoosiers accepted an invitation to play in the Liberty Bowl. Their appearance marked the first for Indiana in the Liberty Bowl, and their fifth overall bowl game.

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