The 1951 Michigan State Spartans football team represented Michigan State College in the 1951 college football season. The Spartans played their home games at Macklin Stadium (now known as Spartan Stadium) in East Lansing, Michigan and were coached by Clarence "Biggie" Munn.

The Spartans went undefeated and were elected the National Champions by the Helms Athletic Foundation; however, the rest of the polls voted for the Tennessee Volunteers, who lost in the Sugar Bowl to the Maryland Terrapins, but postseason games were not considered by the major polls at that time.