The 1946 World Series was played in October 1946 between the St. Louis Cardinals (representing the National League) and the Boston Red Sox (representing the American League). This was the Red Sox's first appearance in a World Series since their championship of 1918.

In the eighth inning of Game 7, with the score 3–3, the Cardinals' Enos Slaughter opened the inning with a single but two batters failed to advance him. With two outs, Harry Walker walloped a hit over Johnny Pesky's head into left-center field. As Leon Culberson chased it down, Slaughter started his "mad dash". Pesky caught Culberson's throw, turned and—perhaps surprised to see Slaughter headed for the plate—supposedly hesitated just a split second before throwing home. Roy Partee had to take a few steps up the third base line to catch Pesky's toss, but Slaughter was safe without a play at the plate and Walker was credited with an RBI double. The Cardinals won the game and the Series in seven games, giving them their sixth championship.

Boston superstar Ted Williams played the Series injured and was largely ineffective but refused to use his injury as an excuse.

As the first World Series to be played after wartime travel restrictions had been lifted, it returned from the 3-4 format to the 2–3–2 format for home teams, which has been used ever since. It also saw the return of many prominent players from military service.

NL St. Louis Cardinals (4) vs. AL Boston Red Sox (3)

The Red Sox won Game 1 when Rudy York hit a home run into the left field bleachers.

The Red Sox scored three runs in the first inning on Rudy York's blast then won by a score of 4–0.

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