1942 U.S. National Championships – Women's Singles
| Women's Singles | |
|---|---|
| 1942 U.S. National Championships | |
| Champion |
 Pauline Betz
|
| Runner-up |
Louise Brough
|
| Final score | 4–6, 6–1, 6–4 |
Second-seeded Pauline Betz defeated first-seeded Louise Brough 4–6, 6–1, 6–4 in the final to win the Women's Singles tennis title at the 1942 U.S. National Championships.
The eight seeded U.S. players are listed below. Sarah Palfrey Cooke is the champion; others show in brackets the round in which they were eliminated.
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