This was the Series of the famous "Mack Attack" (so called in honor of longtime A's owner-manager Connie Mack), in which the Athletics overcame an eight-run deficit by scoring 10 runs in the home half of the seventh in Game 4 (before two straight strikeouts by Pat Malone ended it) to snatch a 10–8 victory from the jaws of a defeat which would have evened the Series at two games apiece. The Cubs were further humiliated in the middle of that record rally when center fielder Hack Wilson lost Mule Haas's fly ball in the sun for a fluke three-run inside-the-park home run, bringing the A's to within a run at 8–7. It was the last occurrence of an inside-the-park home run in a World Series game until Game 1 of the 2015 World Series.

Because seven of the eight regulars in the Cubs' lineup hit right-handed (except for first baseman Charlie Grimm), Mack started only right-handed pitchers and kept all his lefties in the bullpen even though two of his best starters, 300-game-winner-to-be Lefty Grove and Rube Walberg, were southpaws.

Accordingly, Game 1 will be remembered mostly for the surprise start of aging A's pitcher Howard Ehmke, whose record thirteen strikeouts in a stellar complete game 3–1 win bested "Big" Ed Walsh's 1906 Series record by one, and stood until Carl Erskine broke it by one in 1953. Ehmke went on to start Game 5 but failed to get out of the fourth inning, the bullpen and a ninth-inning A's come-from-behind walk-off rally bailing him out.

AL Philadelphia Athletics (4) vs. NL Chicago Cubs (1)

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