1921 U.S. National Championships – Women's Singles
| Women's Singles | |
|---|---|
| 1921 U.S. National Championships | |
| Champion |
 Molla Mallory
|
| Runner-up |
Mary Browne
|
| Final score | 4–6, 6–4, 6–2 |
| Draw | 64 |
| Seeds | – |
Molla Mallory defeated Mary Browne 4–6, 6–4, 6–2 in the final to win the Women's Singles tennis title at the 1921 U.S. National Championships. The event was held at the Germantown Cricket Club in Philadelphia, PA, United States from August 15 through August 20, 1921. It was Mallory's sixth U.S. National singles title.
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