After a two-year hiatus due to World War I, the Indianapolis 500 returned to competition in 1919. Howdy Wilcox won, accompanied by riding mechanic Leo Banks. More than half the field (19 of 33 cars) consisted of rookie drivers, tied for the most ever, excluding the inaugural race where all 40 cars were considered "rookies." Ralph DePalma, the 1915 winner, and the driver who suffered a heartbreaking loss in 1912, again put in a dominating performance, DePalma led 93 of the first 102 laps, and drove the first half at record-breaking speed. Tire problems, however, necessitated a long pit stop, and DePalma finished in 6th place.

Rain was a factor during practice, limiting available track time in the days immediately leading up to time trials. Since most teams did not arrive until later in the month, some cars had very limited preparation time. Qualifying was supposed to be held on just one day, but officials decided to add two additional days due to the lost track time.

The first half of the race was marred by three fatalities. Driver Arthur Thurman died in a crash on lap 45. On lap 96, Louis LeCocq and his riding mechanic Robert Bandini wrecked in turn two, and both were burned to death.

Over two years had gone by since the last competitive events were held at the Speedway. The 1916 race was followed by the Harvest Auto Racing Classic, at which point the track was closed due to the escalation of World War I. When the Armistice was signed in November 1918, the Speedway management was anxious to begin planning for the resumption of the 500 in 1919. Some early rumors circulated that the race may change dates to July 4, or even expand to 1,000 miles. These rumors were briefly entertained when the AAA Contest Board announced that both May 30 and July 4 were being set aside on the calendar for the event.

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