During the 1906–07 English football season, Brentford competed in the Southern League First Division. The highlight of the mid-table season was a run to the third round of the FA Cup.

Following the death of Dick Molyneux, William Brown was appointed Brentford secretary-manager on a permanent basis at the end of the 1905–06 season, having initially been appointed interim manager in February 1906. He retained the Bees' nucleus of players (Watson, Jay, Parsonage, Tomlinson, Corbett, Underwood, Greaves, Shanks) and brought in a new goalkeeper (Williams), two full backs (McConnell and Taylor), half back Haworth and four new forwards (Greechan, Hagan, McAllister and Pentland).