UBQLN2 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|||||||||||||||
Identifiers | |||||||||||||||
Aliases | UBQLN2, ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157, ubiquilin 2 | ||||||||||||||
External IDs | MGI: 1860283 HomoloGene: 81830 GeneCards: UBQLN2 | ||||||||||||||
RNA expression pattern | |||||||||||||||
More reference expression data | |||||||||||||||
Orthologs | |||||||||||||||
Species | Human | Mouse | |||||||||||||
Entrez |
|
|
|||||||||||||
Ensembl |
|
|
|||||||||||||
UniProt |
|
|
|||||||||||||
RefSeq (mRNA) |
|
|
|||||||||||||
RefSeq (protein) |
|
|
|||||||||||||
Location (UCSC) | Chr X: 56.56 – 56.57 Mb | Chr X: 153.5 – 153.5 Mb | |||||||||||||
PubMed search | |||||||||||||||
Ubiquilin-2 is a protein that in humans is encoded by the UBQLN2 gene.
This gene encodes a ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.