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TANK-binding kinase 1

TBK1
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases TBK1, Tbk1, 1200008B05Rik, AI462036, AW048562, NAK, T2K, FTDALS4, TANK binding kinase 1
External IDs HomoloGene: 22742 GeneCards: TBK1
RNA expression pattern
PBB GE TBK1 218520 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013254

n/a

RefSeq (protein)

NP_037386

n/a

Location (UCSC) Chr 12: 64.45 – 64.5 Mb n/a
PubMed search n/a

4EFO, 4EUT, 4EUU, 4IM0, 4IM2, 4IM3, 4IW0, 4IWO, 4IWP, 4IWQ

NM_013254

n/a

NP_037386

n/a

Serine/threonine-protein kinase TBK1 is an enzyme that in humans is encoded by the TBK1 gene.

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.


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Wikipedia

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