SQSTM1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9

Identifiers

Aliases

SQSTM1, A170, OSIL, PDB3, ZIP3, p60, p62, p62B, FTDALS3, Sequestosome 1

External IDs

MGI: 107931 HomoloGene: 31202 GeneCards: SQSTM1

Genetically Related Diseases

Alzheimer's disease

Gene ontology
Molecular function	• protein homodimerization activity • receptor tyrosine kinase binding • zinc ion binding • SH2 domain binding • metal ion binding • protein serine/threonine kinase activity • K63-linked polyubiquitin binding • protein binding • identical protein binding • protein kinase binding • ubiquitin protein ligase binding • protein kinase C binding • ubiquitin binding
Cellular component	• cytoplasm • endosome • PML body • late endosome • P-body • pre-autophagosomal structure • nucleoplasm • aggresome • autophagosome • amphisome • endoplasmic reticulum • inclusion body • lysosome • sperm midpiece • extracellular exosome • cytoplasmic vesicle • nucleus • cytosol • intracellular membrane-bounded organelle • autolysosome
Biological process	• apoptotic process • protein localization • cell differentiation • positive regulation of protein phosphorylation • intracellular signal transduction • ubiquitin-dependent protein catabolic process • negative regulation of growth of symbiont in host • regulation of mitochondrion organization • protein heterooligomerization • immune system process • response to stress • regulation of Ras protein signal transduction • negative regulation of apoptotic process • autophagy • endosomal transport • regulation of protein complex stability • mitophagy • positive regulation of apoptotic process • regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter • protein phosphorylation • macromitophagy • response to mitochondrial depolarisation • macroautophagy
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8878


18412

Ensembl


ENSG00000161011


ENSMUSG00000015837

UniProt


Q13501


Q64337

RefSeq (mRNA)


NM_001142298 NM_001142299 NM_003900


NM_001290769 NM_011018

RefSeq (protein)


NP_001135770 NP_001135771 NP_003891


NP_001277698.1 NP_035148.1 NP_001277698 NP_035148

Location (UCSC)

Chr 5: 179.81 – 179.84 Mb

Chr 11: 50.2 – 50.21 Mb

PubMed search

1Q02, 2JY7, 2JY8, 2K0B, 2KNV, 4MJS, 4UF8, 4UF9

NM_001142298
NM_001142299
NM_003900

NM_001290769
NM_011018

NP_001135770
NP_001135771
NP_003891

...
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