PROUD (clinical trial)

PROUD (a backronym for "Pre-exposure Option for reducing HIV in the UK: immediate or Deferred") was an open-label randomised clinical trial of pre-exposure prophylaxis (PrEP) by the MRC Clinical Trials Unit at University College London. It sought to evaluate the effectiveness of PrEP at preventing the spread of HIV in sexually active gay men in a non-controlled real-world environment. The study recruited participants at several different locations: Brighton, Birmingham, York, Manchester, Sheffield, and eight locations in London.

The trial reported PrEP to have an 86% effectiveness in preventing HIV infection.