PIN1

PIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1F8A, 1I6C, 1I8G, 1I8H, 1NMV, 1NMW, 1PIN, 1ZCN, 2F21, 2ITK, 2KBU, 2KCF, 2LB3, 2M8I, 2M8J, 2M9E, 2M9F, 2M9I, 2M9J, 2Q5A, 2RUC, 2RUD, 2XP3, 2XP4, 2XP5, 2XP6, 2XP7, 2XP8, 2XP9, 2XPA, 2XPB, 2ZQS, 2ZQT, 2ZQU, 2ZQV, 2ZR4, 2ZR5, 2ZR6, 3I6C, 3IK8, 3IKD, 3IKG, 3JYJ, 3KAB, 3KAC, 3KAD, 3KAF, 3KAG, 3KAH, 3KAI, 3KCE, 3NTP, 3ODK, 3OOB, 3TC5, 3TCZ, 3TDB, 3WH0, 4GWT, 4GWV, 4QIB, 4TNS, 4TYO, 4U84, 4U85, 4U86, 2RUQ, 2N1O, 2RUR
Identifiers
Aliases	PIN1, DOD, UBL5, peptidylprolyl cis/trans isomerase, NIMA-interacting 1
External IDs	MGI: 1346036 HomoloGene: 4531 GeneCards: PIN1
Gene ontology Molecular function • GTPase activating protein binding • beta-catenin binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • protein binding • mitogen-activated protein kinase kinase binding • motor activity • phosphoserine binding • phosphothreonine binding Cellular component • cytoplasm • cytosol • nuclear speck • midbody • mitochondrion • neuron projection • nucleus • nucleoplasm Biological process • negative regulation of neuron apoptotic process • positive regulation of protein phosphorylation • regulation of cytokinesis • positive regulation of protein dephosphorylation • negative regulation of protein catabolic process • positive regulation of canonical Wnt signaling pathway • synapse organization • negative regulation of cell motility • protein stabilization • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of protein binding • protein peptidyl-prolyl isomerization • regulation of protein localization to nucleus • positive regulation of GTPase activity • positive regulation of neuron apoptotic process • positive regulation of ubiquitin-protein transferase activity • neuron differentiation • negative regulation of ERK1 and ERK2 cascade • cell cycle • negative regulation of type I interferon production • positive regulation of cell growth involved in cardiac muscle cell development • regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of transcription from RNA polymerase II promoter • regulation of mitotic nuclear division • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5300	23988
Ensembl	ENSG00000127445	ENSMUSG00000032171
UniProt	Q13526	Q9QUR7
RefSeq (mRNA)	NM_006221	NM_023371
RefSeq (protein)	NP_006212	NP_075860.1 NP_075860
Location (UCSC)	Chr 19: 9.84 – 9.85 Mb	Chr 9: 20.65 – 20.67 Mb
PubMed search

1F8A, 1I6C, 1I8G, 1I8H, 1NMV, 1NMW, 1PIN, 1ZCN, 2F21, 2ITK, 2KBU, 2KCF, 2LB3, 2M8I, 2M8J, 2M9E, 2M9F, 2M9I, 2M9J, 2Q5A, 2RUC, 2RUD, 2XP3, 2XP4, 2XP5, 2XP6, 2XP7, 2XP8, 2XP9, 2XPA, 2XPB, 2ZQS, 2ZQT, 2ZQU, 2ZQV, 2ZR4, 2ZR5, 2ZR6, 3I6C, 3IK8, 3IKD, 3IKG, 3JYJ, 3KAB, 3KAC, 3KAD, 3KAF, 3KAG, 3KAH, 3KAI, 3KCE, 3NTP, 3ODK, 3OOB, 3TC5, 3TCZ, 3TDB, 3WH0, 4GWT, 4GWV, 4QIB, 4TNS, 4TYO, 4U84, 4U85, 4U86, 2RUQ, 2N1O, 2RUR

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