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Methuselah Mouse Prize

Methuselah Foundation
Methuselah Foundation Logo
Founded 2003
Type 501(c)(3)
Focus Life extension, rejuvenation, tissue engineering
Location
Area served
Global
Method New Organ Prize, Mprize, Research Grants, Angel Investing
Slogan Extending Healthy Life
Website www.methuselahfoundation.org

Methuselah Foundation is a non-profit organization dedicated to extending the healthy human lifespan by advancing tissue engineering and regenerative medicine therapies. It was co-founded in 2003 by Aubrey de Grey and David Gobel, and is based in Springfield, Virginia, United States. According to its website, Methuselah has given more than $4 million to support research and development in regenerative medicine.

In 2003, David Gobel seed-funded the Methuselah Mouse Prize (Mprize) to encourage the development of new life extension therapies in mice, which are genetically similar to humans. So far, three Mouse Prizes have been awarded: one for breaking longevity records to Andrzej Bartke of Southern Illinois University; one for late-onset rejuvenation strategies to Stephen Spindler of the University of California; and one to Z. Dave Sharp for his work with the pharmaceutical rapamycin.

On May 30, 2014, at the 43rd Annual Meeting of the American Aging Association, Methuselah awarded a $10,000 Mprize to Huber Warner for his founding of the National Institute on Aging’s Interventions Testing Program. Warner is a former program director for the NIA Biology of Aging Program and former Associate Dean of Research for the College of Biological Sciences at the University of Minnesota.

In 2013, Methuselah launched a second prize series, entitled New Organ, to accelerate solutions to the global organ shortage. The first prize in this series, the $1 million New Organ Liver Prize, “will award $1,000,000 to the first team that creates a bioengineered replacement for the native liver of a large mammal, enabling it to recover in the absence of native function and survive three months with a normal lifestyle.” Future prizes under consideration include awards for the “heart, lung, and kidney.”

In 2016, Methuselah foundation partnered with NASA to create the Vascular Tissue Challenge. Under this prize, teams will compete to "successfully create thick, human vascularized organ tissue in an in-vitro environment while maintaining metabolic functionality similar to their in vivo native cells throughout a 30-day survival period." A $500,000 prize purse will be divided among the first three teams that can successfully complete the challenge. Thick-tissue vascularization is one of the critical enabling challenges in tissue engineering that would be required to be overcome to produce the tissues and organs for patients in need.


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