Keratoepithelin

TGFBI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X3B, 2LTB, 2LTC, 2VXP
Identifiers
Aliases	TGFBI, BIGH3, CDB1, CDG2, CDGG1, CSD, CSD1, CSD2, CSD3, EBMD, LCD1, transforming growth factor beta induced
External IDs	MGI: 99959 HomoloGene: 37294 GeneCards: TGFBI
Gene ontology Molecular function • integrin binding • protein binding • collagen binding • extracellular matrix binding Cellular component • extracellular matrix • extracellular region • basement membrane • trans-Golgi network • plasma membrane • extracellular exosome • extracellular space • proteinaceous extracellular matrix Biological process • cellular protein metabolic process • negative regulation of cell adhesion • cell proliferation • chondrocyte differentiation • angiogenesis • response to stimulus • visual perception • cell adhesion • extracellular matrix organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7045	21810
Ensembl	ENSG00000120708	ENSMUSG00000035493
UniProt	Q15582	P82198
RefSeq (mRNA)	NM_000358	NM_009369
RefSeq (protein)	NP_000349	NP_033395.1 NP_033395
Location (UCSC)	Chr 5: 136.03 – 136.06 Mb	Chr 13: 56.61 – 56.64 Mb
PubMed search

1X3B, 2LTB, 2LTC, 2VXP

7045

21810

ENSG00000120708

ENSMUSG00000035493

Q15582

P82198

NM_000358

NM_009369

NP_000349

NP_033395.1
NP_033395

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a protein which in humans is encoded by the TGFBI gene, locus 5q31.

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion.

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Wikipedia