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Global microbial identifier


The genomic epidemiological database for global identification of microorganisms or global microbial identifier (GMI) is a platform for storing whole genome sequencing (WGS) data of microorganisms, for the identification of relevant genes and for the comparison of genomes to detect and track-and-trace infectious disease outbreaks and emerging pathogens. The database holds two types of information: 1) genomic information of microorganisms, linked to, 2) metadata of those microorganism such as epidemiological details. The database includes all genera of microorganisms: bacteria, viruses, parasites and fungi.

For genotyping of microorganisms for medical diagnosis, or other purposes, scientists may use a wide variety of DNA profiling techniques, such as PCR, PFGE and MLST. A complication of this broad variety of pre-WGS techniques is the difficulty to standardize between techniques, laboratories and microorganisms, which may be overcome using the complete DNA code of the genome generated by WGS techniques. For straight forward diagnostic identification the WGS information of a microbiological sample is fed into a global genomic database and compared using BLAST procedures to the genomes already present in the database. In addition, WGS data may be used to back calculate to the different pre-WGS genotyping methods, so previous collected valuable information is not lost. For the global microbial identifier the genomic information is coupled to a wide spectrum of metadata about the specific microbial clone and includes important clinical and epidemiological information such as the global finding place(s), treatment options and antimicrobial resistance, making it a general microbiological identification tool.This makes personalized treatment of microbial disease possible as well as real-time tracing systems for global surveillance of infectious diseases for food safety and serving human health.


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