FOXO3

FOXO3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K86, 2LQH, 2LQI, 2UZK
Identifiers
Aliases	FOXO3, AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A, forkhead box O3
External IDs	MGI: 1890081 HomoloGene: 31039 GeneCards: FOXO3
Gene ontology Molecular function • beta-catenin binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • protein binding • transcription cofactor binding • protein kinase binding • chromatin DNA binding • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • core promoter binding • DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding Cellular component • membrane • nucleoplasm • nucleus • cytosol • cytoplasm • mitochondrion Biological process • initiation of primordial ovarian follicle growth • ovulation from ovarian follicle • regulation of transcription, DNA-templated • antral ovarian follicle growth • positive regulation of erythrocyte differentiation • glucose homeostasis • DNA damage response, signal transduction by p53 class mediator • tumor necrosis factor-mediated signaling pathway • regulation of reactive oxygen species metabolic process • transcription from RNA polymerase II promoter • regulation of neural precursor cell proliferation • transcription, DNA-templated • neuronal stem cell population maintenance • positive regulation of neuron apoptotic process • oocyte maturation • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of apoptotic process • regulation of translation • negative regulation of canonical Wnt signaling pathway • apoptotic process • negative regulation of transcription from RNA polymerase II promoter • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • cellular response to oxidative stress • positive regulation of transcription, DNA-templated • positive regulation of reactive oxygen species biosynthetic process • brain morphogenesis • aging • negative regulation of neuron differentiation • cellular response to hypoxia • response to water-immersion restraint stress • response to nutrient levels • cellular response to beta-amyloid • cellular response to corticosterone stimulus • positive regulation of endothelial cell apoptotic process • positive regulation of hydrogen peroxide-mediated programmed cell death • response to dexamethasone • cellular response to nerve growth factor stimulus • cellular response to glucose stimulus • response to drug Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2309	56484
Ensembl	ENSG00000118689	ENSMUSG00000048756
UniProt	O43524	Q9WVH4
RefSeq (mRNA)	NM_001455 NM_201559	NM_019740
RefSeq (protein)	NP_001446 NP_963853	NP_062714.1 NP_062714
Location (UCSC)	Chr 6: 108.56 – 108.68 Mb	Chr 10: 42.18 – 42.28 Mb
PubMed search

2K86, 2LQH, 2LQI, 2UZK

2309

56484

ENSG00000118689

ENSMUSG00000048756

O43524

Q9WVH4

NM_001455
NM_201559

NM_019740

NP_001446
NP_963853

NP_062714.1
NP_062714

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.

FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-binding domain. There are three other FoxO family members in humans, FOXO1, FOXO4 and FOXO6. These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by proteins such as Akt/PKB in the PI3K signaling pathway (aside from FOXO6, which may be constitutively nuclear). Other post-translational modifications including acetylation and methylation are seen and can result in increased or altered FOXO3a activity.

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Wikipedia