Desmoglein 3

DSG3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5EQX
Identifiers
Aliases	DSG3, CDHF6, PVA, desmoglein 3
External IDs	MGI: 99499 HomoloGene: 55513 GeneCards: DSG3
Gene ontology Molecular function • calcium ion binding • metal ion binding Cellular component • integral component of membrane • cytosol • cell junction • desmosome • extracellular exosome • membrane • plasma membrane • cornified envelope Biological process • cell adhesion • homophilic cell adhesion via plasma membrane adhesion molecules • keratinization • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1830	13512
Ensembl	ENSG00000134757	ENSMUSG00000056632
UniProt	P32926	O35902
RefSeq (mRNA)	NM_001944	NM_030596
RefSeq (protein)	NP_001935	NP_085099.2 NP_085099
Location (UCSC)	Chr 18: 31.45 – 31.48 Mb	Chr 18: 20.51 – 20.54 Mb
PubMed search

5EQX

1830

13512

ENSG00000134757

ENSMUSG00000056632

P32926

O35902

NM_001944

NM_030596

NP_001935

NP_085099.2
NP_085099

Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.

Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.

Desmoglein 3 has been shown to interact with PKP3.

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Wikipedia