Deglycyrrhizinated licorice

Deglycyrrhizinated licorice, or DGL, is an herbal supplement typically used in the treatment of gastric and duodenal ulcers. It is made from licorice from which the glycyrrhizin has been removed.

Deglycyrrhizinated liquorice plus antacid is marketed in Europe, South Africa, and Canada, as the medicinal preparation Caved-S. In the United States, DGL is marketed as an herbal supplement.

Glycyrrhizin is known to cause negative side effects, such as hypertension and edema; removing the glycyrrhizin is meant to avoid these symptoms.

According to MedlinePlus and the Natural Medicines Comprehensive Database, licorice is "possibly effective" for dyspepsia in combination with other herbs, but there is "insufficient evidence" to rate its effectiveness for other conditions. Regarding stomach ulcers, specifically, there is "some evidence...that specially prepared licorice will speed the healing of stomach ulcers".

An un-blinded study of 82 patients from the early 1980s, published in the British Medical Journal, reported that Caved-S had a therapeutic effect similar to that of cimetidine in the treatment of gastric ulcers.

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