The Caloosahatchee River is a river on the southwest Gulf Coast of Florida in the United States, approximately 67 miles (108 km) long. It drains rural areas on the northern edge of the Everglades, east of Fort Myers. An important link in the Okeechobee Waterway, a manmade inland waterway system of southern Florida, the river forms a tidal estuary along most of its course and has recently become the subject of efforts to restore and preserve the Everglades.
The river issues from Lake Hicpochee, in southeastern Glades County, approximately 10 mi (16 km) west of Clewiston. It flows west-southwest past LaBelle, where it becomes tidal, forming an estuary along its lower 25 mi (40 km). It broadens as it nears the gulf, passing Fort Myers and Cape Coral. It enters the Gulf of Mexico 10 mi (16 km) southwest of Fort Myers in San Carlos Bay, protected by Sanibel Island.
The 5 mi (8 km) Caloosahatchee Canal connecting Lake Hicpochee to Lake Okeechobee allows continuous navigation from the Caloosahatchee to the Okeechobee Waterway system; oxbow lakes mark isolated stretches of the original waterway. In 2013 heavy rains in southern Florida resulted in high runoff into Lake Okeechobee; rising lake levels forced the United States Army Corps of Engineers to release large volumes of polluted water from the lake through the St. Lucie River estuary to the east and the Caloosahatchee River estuary to the west. Thus the normal mix of fresh and salt water in those estuaries was replaced by a flood of polluted fresh water resulting in ecological damage.