CHMP2B

CHMP2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JQK
Identifiers
Aliases	CHMP2B, ALS17, CHMP2.5, DMT1, VPS2-2, VPS2B, charged multivesicular body protein 2B
External IDs	MGI: 1916192 HomoloGene: 8534 GeneCards: CHMP2B
Gene ontology Molecular function • protein domain specific binding • protein binding • cadherin binding involved in cell-cell adhesion Cellular component • cytoplasm • ESCRT III complex • cytosol • endosome • late endosome • late endosome membrane • membrane • plasma membrane • intracellular • lysosome • extracellular exosome • cell-cell adherens junction Biological process • regulation of centrosome duplication • viral budding via host ESCRT complex • cognition • nucleus organization • viral life cycle • neuron cellular homeostasis • multivesicular body assembly • regulation of mitotic spindle assembly • endosome organization • autophagy • endosomal transport • transport • protein transport • positive regulation of viral release from host cell • cell separation after cytokinesis • mitotic metaphase plate congression • vacuolar transport • ESCRT III complex disassembly • cell-cell adhesion • macroautophagy • multivesicular body-lysosome fusion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	25978	68942
Ensembl	ENSG00000083937	ENSMUSG00000004843
UniProt	Q9UQN3	Q8BJF9
RefSeq (mRNA)	NM_001244644 NM_014043	NM_026879
RefSeq (protein)	NP_001231573 NP_054762	NP_081155.1 NP_081155
Location (UCSC)	Chr 3: 87.23 – 87.26 Mb	Chr 16: 65.54 – 65.56 Mb
PubMed search

2JQK

25978

68942

ENSG00000083937

ENSMUSG00000004843

Q9UQN3

Q8BJF9

NM_001244644
NM_014043

NM_026879

NP_001231573
NP_054762

NP_081155.1
NP_081155

Charged multivesicular body protein 2b is a protein that in humans is encoded by the CHMP2B gene.

Mutations of this gene cause chromosome 3-linked frontotemporal dementia (FTD3; OMIM 600795)

In French families with frontotemporal dementia, CHMP2B mutations were found to be a rare cause of the disease.

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Wikipedia