UFC on Fox: Velasquez vs. dos Santos (also known as UFC on Fox 1) was a mixed martial arts event held by the Ultimate Fighting Championship on November 12, 2011 at the Honda Center in Anaheim, California.

This card marked the UFC's debut on the Fox Network. Zuffa CEO Lorenzo Fertitta confirmed that the debut show would be a one-hour special with only the main event airing live on television, but a full preliminary card taking place beforehand.

Fox Deportes aired the Guida/Henderson, Poirer/Garza, Swanson/Lamas and Johnson/Harvison fights.

The winner of the Clay Guida/Benson Henderson fight determined who was next to get a title shot against Frankie Edgar (the reigning champion at the time), at UFC 144 in Japan.

The UFC on Fox main event broadcast marked the most-watched live hour ever for MMA in the United States and averaged 5.7 million viewers. The ratings peaked in the United States at 8.8 million viewers for the main event.

Fighters were awarded $65,000 bonuses.

The following is the reported payout to the fighters as reported to the California State Athletic Commission. It does not include sponsor money or "locker room" bonuses often given by the UFC and also do not include the UFC's traditional "fight night" bonuses.

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