UFC on Fox: Henderson vs. Diaz (also known as UFC on Fox 5) is a mixed martial arts event that was held by the Ultimate Fighting Championship on December 8, 2012 at KeyArena in Seattle, Washington. It was broadcast live on Fox Sports.

As a result of the cancellation of UFC 151, bouts between Tim Means vs. Abel Trujillo, Daron Cruickshank vs. Henry Martinez and Dennis Siver vs. Eddie Yagin were rescheduled for this event.

Rafaello Oliveira was expected to face Michael Chiesa at the event. However, Oliveira was forced out of the bout with a broken hand, and replaced by Marcus LeVesseur. Then, the week of the event, Chiesa was forced out of the bout with LeVesseur with an undisclosed illness and the bout was scrapped altogether. Also, on the day of the weigh-ins for the event, Tim Means was forced from his bout with Abel Trujillo after sustaining a head injury caused by a fall in a hotel sauna. LeVesseur replaced Means in the bout.

T.J. Dillashaw was scheduled to fight Mike Easton in the preliminary card. However, an injury sidelined Dillashaw, who was forced out of the bout and replaced by Bryan Caraway. Then, on November 21, it was announced that Caraway was forced out of the bout with an injury and replaced by Raphael Assunção.

Eddie Yagin was expected to face Dennis Siver at this event. However, Yagin was forced out of the bout due to a sparring injury that landed him in the hospital with swelling around his brain, and was replaced by Nam Phan.

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