UFC Live: Jones vs. Matyushenko (also known as UFC on Versus 2) was a mixed martial arts event held by the Ultimate Fighting Championship on Sunday, August 1, 2010. Originally scheduled to take place at the EnergySolutions Arena in Salt Lake City, Utah, the UFC was forced to move the event to a different venue due to low ticket sales. On June 14, 2010, the event was moved to San Diego, California to be held at the Valley View Casino Center. The event was the second UFC event to be broadcast on Versus; the first being UFC Live: Vera vs. Jones.

Jim Miller and Gleison Tibau were set to fight at this event, but the bout was later moved to UFC Fight Night: Marquardt vs. Palhares the following month.

Two bouts were moved to this event due to visa issues; Paul Kelly vs. Jacob Volkmann from UFC 116 and Darren Elkins vs. Charles Oliveira from The Ultimate Fighter 11 Finale.

Joe Stevenson suffered a knee injury in training and was unable to fight Takanori Gomi. Stevenson was replaced by Tyson Griffin.

Willamy Freire also suffered an injury in training, forcing the cancellation of his fight with Thiago Thavares. Thavares was then pulled from the card altogether.

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