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Smart ligand


Smart ligands are affinity ligands selected with pre-defined equilibrium (), kinetic (, ) and thermodynamic (ΔH, ΔS) parameters of biomolecular interaction.

Ligands with desired parameters can be selected from large combinatorial libraries of biopolymers using instrumental separation techniques with well-described kinetic behaviour, such as kinetic capillary electrophoresis (KCE), surface plasmon resonance (SPR), microscale thermophoresis (MST), etc. Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed.


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Wikipedia

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