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Perfluorooctanoic acid

Perfluorooctanoic acid
Perfluorooctanoic acid.png
PFOA-3D.png
Names
IUPAC name
pentadecafluorooctanoic acid
Other names
perfluorooctanoic acid, PFOA, C8, perfluorooctanoate, perfluorocaprylic acid, FC-143, F-n-octanoic acid, PFO
Identifiers
335-67-1 YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:35549 YesY
ChEMBL ChEMBL172988 YesY
ChemSpider 9180 YesY
ECHA InfoCard 100.005.817
EC Number 206-397-9
PubChem 9554
RTECS number RH0781000
Properties
C8HF15O2
Molar mass 414.07 g/mol
Appearance colorless liquid
Density 1.8 g/cm3
Melting point 40 to 50 °C (104 to 122 °F; 313 to 323 K)
Boiling point 189 to 192 °C (372 to 378 °F; 462 to 465 K)
soluble, 9.5 g/L (PFO)
Solubility in other solvents polar organic
solvents
Acidity (pKa) ~0
Hazards
Main hazards Strong Acid, Causes Burns
Safety data sheet
R-phrases R22 R34 R52/53
S-phrases S26 S36/37/39 S45
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 3: Short exposure could cause serious temporary or residual injury. E.g., chlorine gas Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Related compounds
Related compounds
 Perfluorooctanesulfonic acid (PFOS), Perfluorononanoic acid (PFNA), Perfluorooctanesulfonamide (PFOSA), Trifluoroacetic acid (TFA)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY  (what is YesYN ?)
Infobox references

Perfluorooctanoic acid (PFOA) (conjugate base perfluorooctanoate), also known as C8, is a synthetic perfluorinated carboxylic acid and fluorosurfactant. One industrial application is as a surfactant in the emulsion polymerization of fluoropolymers. It has been used in the manufacture of such prominent consumer goods as polytetrafluoroethylene (commercially known as Teflon). PFOA has been manufactured since the 1940s in industrial quantities. It is also formed by the degradation of precursors such as some fluorotelomers.

PFOA persists indefinitely in the environment. It is a toxicant and carcinogen in animals. PFOA has been detected in the blood of more than 98% of the general US population in the low and sub-parts per billion range, and levels are higher in chemical plant employees and surrounding subpopulations. How general populations are exposed to PFOA is not completely understood. PFOA has been detected in industrial waste, stain resistant carpets, carpet cleaning liquids, house dust, microwave popcorn bags, water, food, some cookware and PTFE such as Teflon.

As a result of a class-action lawsuit and community settlement with DuPont, three epidemiologists conducted studies on the population surrounding a chemical plant that was exposed to PFOA at levels greater than in the general population. The studies concluded that there was probably an association between PFOA exposure and six health outcomes: kidney cancer, testicular cancer, ulcerative colitis, thyroid disease, hypercholesterolemia (high cholesterol), and pregnancy-induced hypertension.


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