Optineurin

OPTN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LO4, 2LUE, 5AAZ
Identifiers
Aliases	OPTN, ALS12, FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, optineurin
External IDs	MGI: 1918898 HomoloGene: 11085 GeneCards: OPTN
Genetically Related Diseases
mammary Paget's disease
Gene ontology Molecular function • protein binding, bridging • Rab GTPase binding • protein C-terminus binding • ubiquitin binding • protein binding • identical protein binding • K63-linked polyubiquitin binding • metal ion binding • polyubiquitin binding Cellular component • recycling endosome • endosome • Golgi membrane • nucleoplasm • autophagosome • trans-Golgi network • perinuclear region of cytoplasm • nucleus • Golgi apparatus • cytoplasm • cytosol • recycling endosome membrane • cytoplasmic vesicle Biological process • Golgi organization • cell death • negative regulation of I-kappaB kinase/NF-kappaB signaling • autophagy • protein targeting to Golgi • cellular protein localization • G2/M transition of mitotic cell cycle • defense response to Gram-negative bacterium • negative regulation of receptor recycling • vesicle-mediated transport • regulation of I-kappaB kinase/NF-kappaB signaling • signal transduction • Golgi to plasma membrane protein transport • parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization • membrane organization • positive regulation of xenophagy • positive regulation of autophagy • cellular response to unfolded protein • Golgi ribbon formation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10133	71648
Ensembl	ENSG00000123240	ENSMUSG00000026672
UniProt	Q96CV9	Q8K3K8
RefSeq (mRNA)	NM_001008211 NM_001008212 NM_001008213 NM_021980	NM_181848
RefSeq (protein)	NP_001008212 NP_001008213 NP_001008214 NP_068815	NP_862896.1 NP_862896
Location (UCSC)	Chr 10: 13.1 – 13.14 Mb	Chr 2: 5.02 – 5.06 Mb
PubMed search

2LO4, 2LUE, 5AAZ

10133

71648

ENSG00000123240

ENSMUSG00000026672

Q96CV9

Q8K3K8

NM_001008211
NM_001008212
NM_001008213
NM_021980

NM_181848

NP_001008212
NP_001008213
NP_001008214
NP_068815

NP_862896.1
NP_862896

Optineurin is a protein that in humans is encoded by the OPTN gene.

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Wikipedia