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  • Hypercholesterolemia

    Hypercholesterolemia

    • Hypercholesterolemia
      Synonyms hypercholesterolaemia, elevated cholesterol
      Cholesterol.svg
      Formula structure of cholesterol
      Classification and external resources
      Specialty Cardiology
      ICD-10 E78.0
      ICD-9-CM 272.0
      DiseasesDB 6226
      MedlinePlus 000403
      eMedicine med/1073
      MeSH D006937
      []

      Hypercholesterolemia, also called dyslipidemia, is the presence of high levels of cholesterol in the blood. It is a form of high blood lipids and "hyperlipoproteinemia" (elevated levels of lipoproteins in the blood).

      Elevated levels of non-HDL cholesterol and LDL in the blood may be a consequence of diet, obesity, inherited (genetic) diseases (such as LDL receptor mutations in familial hypercholesterolemia), or the presence of other diseases such as diabetes and an underactive thyroid.

      Cholesterol is one of three major classes of lipids which all animal cells use to construct their membranes and is thus manufactured by all animal cells. Plant cells do not manufacture cholesterol. It is also the precursor of the steroid hormones and bile acids. Since cholesterol is insoluble in water, it is transported in the blood plasma within protein particles (lipoproteins). Lipoproteins are classified by their density: very low density lipoprotein (VLDL), low density lipoprotein (LDL), intermediate density lipoprotein (IDL) and high density lipoprotein (HDL). All the lipoproteins carry cholesterol, but elevated levels of the lipoproteins other than HDL (termed non-HDL cholesterol), particularly LDL-cholesterol, are associated with an increased risk of atherosclerosis and coronary heart disease. In contrast, higher levels of HDL cholesterol are protective.


      Interpretation of cholesterol levels
      cholesterol type mg/dL mmol/L interpretation
      total cholesterol <200 <5.2 desirable
      200-239 5.2-6.2 borderline
      >240 >6.2 high
      LDL cholesterol <100 <2.6 most desirable
      100-129 2.6-3.3 good
      130-159 3.4-4.1 borderline high
      160-189 4.1-4.9 high and undesirable
      >190 >4.9 very high
      HDL cholesterol <40 <1.0 undesirable; risk increased
      41-59 1.0-1.5 okay, but not optimal
      >60 >1.55 good; risk lowered
      Indications to lower LDL cholesterol
      Coronary risk because they have... should consider reduction indicated
      high >20% risk of MI in 10 years, or risk factor such as coronary heart disease, diabetes, peripheral-artery disease, carotid-artery disease, or aortic aneurysm >70 mg/dL, 3.88 mmol/L especially if there are risk factors >100 mg/dL, 5.55 mmol/L
      moderately high 10-20% risk of MI in 10 years and > 1 risk factors >100 mg/dL, 5.55 mmol/L >130 mg/dL, 7.21 mmol/L
      moderate <10% risk of MI in 10 years > 1 risk factors >130 mg/dL, 7.21 mmol/L >160 mg/dL, 8.88 mmol/L
      low No or one risk factor >160 mg/dL, 8.88 mmol/L >190 mg/dL, 10.5 mmol/L

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